2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

Related Products

PDF 2.76 MB

Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-106077
    Meteneprost
    Meteneprost (U 46785) is a cervical dilator that stimulates uterine contractions and dilates the cervical canal.
    Meteneprost
  • HY-118488
    L 640035
    		Antagonist
    L 640035 is athromboxaneantagonist.
    L 640035
  • HY-170698
    13,14-Dihydro-15-keto-tetranor prostaglandin E2
    13,14-Dihydro-15-keto-tetranor prostaglandin E2 (13,14-Dihydro-15-keto-tetranor PGE2) is a potential metabolite of Prostaglandin E2 (HY-101952).
    13,14-Dihydro-15-keto-tetranor prostaglandin E2
  • HY-113481A
    17-trans Prostaglandin E3
    		Control
    17-trans Prostaglandin E3 is a prostaglandin analog, and stimulates Nurr1-dependent transcriptional activity. 17-trans Prostaglandin E3 can be used for research of condition associated with Nurr1,such as cancer and autoimmune disease.
    17-trans Prostaglandin E3
  • HY-120867
    TASP0376377
    		Antagonist
    TASP0376377 is a potent and selective CRTH2 antagonist (IC50: 13 nM). TASP0376377 has binding affinity for CRTH2 (IC50: 19 nM).
    TASP0376377
  • HY-139124
    15(R)-15-Methyl Prostaglandin F2α
    		Agonist
    15(R)-15-Methyl Prostaglandin F2α (15(R)-Carboprost; 15(R)-15-methyl PGF2α) is a metabolically stable analog of PGF2α. 15(R)-15-Methyl Prostaglandin F2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-Methyl Prostaglandin F2α converts it into the active 15(S)-isomer. The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.
    15(R)-15-Methyl Prostaglandin F2α
  • HY-B0577R
    Latanoprost (Standard)
    		Agonist
    Latanoprost (Standard) is the analytical standard of Latanoprost. This product is intended for research and analytical applications. Latanoprost (PHXA41) is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).
    Latanoprost (Standard)
  • HY-105120A
    Vapiprost hydrochloride
    Vapiprost hydrochloride (GR 32191 hydrochloride) is a thromboxane A2 receptor antagonist. Vapiprost hydrochloride (GR 32191 hydrochloride) inhibits the aggregation and ATP release stimulated with U-46619, collagen or arachidonic acid (AA) at an IC50 of less than 2.1×10-8 M.
    Vapiprost hydrochloride
  • HY-137227
    15(R)-PTA2
    		Control
    15(R)-PTA2 (15(R)-Pinanethromboxane A2) is an antithrombotic agent that inhibits platelet aggregation. 15(R)-PTA2 inhibits stable prostaglandin endoperoxide analog-induced constriction of feline coronary arteries and stabilizes hepatic lysosomes. 15(R)-PTA2 also inhibits thromboxane synthase but has no effect on prostacyclin synthase.
    15(R)-PTA2
  • HY-118414
    20-Ethyl prostaglandin E2
    20-Ethyl prostaglandin E2 (compound 62) is a PG analog that stimulates Nurr1-dependent transcriptional activity.
    20-Ethyl prostaglandin E2
  • HY-170586
    JAK05
    		Modulator
    JAK05 exhibits inhibitory activity against Helicobacter pylori, inhibits strains J63, J196 and J107 with MIC of 3-5 µg/mL. JAK05 exhibits binding affinity to H+/K+-ATPase, COX-1/2, TNF-α and PGE2, reveals antioxidant and anti-inflammatory activities. JAK05 exhibits anti-ulcer activity in rat ethanol-induced gastric ulcer models.
    JAK05
  • HY-B0584A
    5,6-trans-Travoprost
    		Agonist
    5,6-trans-Travoprost is the isomer of Travoprost (HY-B0584), and can be used as an experimental control. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension.
    5,6-trans-Travoprost
  • HY-118648
    Prostaglandin F2α methyl ester
    		Agonist
    Prostaglandin F2α methyl ester (PGF2α methyl ester; Dinoprost methyl) is a PGF2α analog with more lipid solubility. Prostaglandin F2α methyl ester exhibits efficacy in maintaining the ocular hypotensive.
    Prostaglandin F2α methyl ester
  • HY-N10225
    Thielavin A
    		Inhibitor
    Thielavin A is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin A specifically inhibits the conversion of arachidonic acid into prostaglandin H2. Thielavin A has no anti-inflammatory activity on intravenous injection or on oral administration.
    Thielavin A
  • HY-157495
    EP3 antagonist 6
    		Antagonist
    EP3 antagonist 6 (compound 5) is a potent, orally and selective EP3 receptor antagonist, with an IC50 of 1.9 nM. EP3 antagonist 6 can inhibits PGE2-induced (HY-101952) uterine contraction in pregnant rats.
    EP3 antagonist 6
  • HY-139121
    15(R)-17-Phenyl trinor Prostaglandin F2α
    		Agonist
    15(R)-17-Phenyl trinor Prostaglandin F2α (15-epi Bimatoprost free acid) is a prostaglandin F (FP) analog that acts as an ocular hypotensive agent. The free acid 17-Phenyl trinor Prostaglandin F2α is a potent FP receptor agonist. 15(R)-17-Phenyl trinor Prostaglandin F2α is the 15-epi or "unnatural" isomer of this active free acid metabolite and has reduced FP receptor agonist activity.
    15(R)-17-Phenyl trinor Prostaglandin F2α
  • HY-101236
    ICI 192605
    		Antagonist
    ICI 192605 is a potent TXA2R (thromboxane A2 receptor) antagonist as cell signaling prostaglandin. ICI 192605 blocks contraction of isolated guinea pig trachea induced by U-46619.
    ICI 192605
  • HY-116733
    Tafluprost ethyl ester
    		Agonist
    Tafluprost ethyl ester (AFP-175) is a derivative of Prostaglandin F2α (PGF2α) (HY-12956). Tafluprost ethyl ester is an agonist for prostaglandin FP receptor, and exhibits miotic effect.
    Tafluprost ethyl ester
  • HY-114385
    13,14-epoxy Travoprost
    		Control
    13,14-epoxy Travoprost (13,14-epoxy Fluprostenol isopropyl ester) is a mixture of diastereomeric epoxides generated during production of Travoprost (HY-B0584). Travoprost is a selective agonist for prostaglandin F receptor, which exhibits an ocular hypotensive efficacy.
    13,14-epoxy Travoprost
  • HY-123123
    RS-61756-007
    		Inhibitor
    RS-61756-007 is a selective thromboxane receptor (TP) agonist with high activity at the TP receptor. RS-61756-007 showed agonism at TP and FP receptors in in vitro studies but had no activity at other receptor subtypes. The effects of RS-61756-007 can be antagonized in a similar manner by the TP antagonist SQ 29,548.
    RS-61756-007
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.